Raloxifene 60 mg tablet (Evista) is a selective estrogen receptor modulator (SERM) that is used to prevent and treat osteoporosis in postmenopausal women. It is also used to reduce the risk of invasive breast cancer in women at high risk. Raloxifene and weight gain – know more about this
It is a possible side effect of this medicine, but it is not common. In clinical trials, about 2% of women who took raloxifene gained 5% or more of their body weight, compared to about 1% of women who took a placebo.
The exact cause of weight gain on raloxifene is not known. However, it is thought to be related to the drug’s effects on metabolism and appetite. Raloxifene may also cause fluid retention, which can contribute to weight gain.
If you are concerned about weight gain on raloxifene, talk to your doctor. They can help you develop a plan to maintain a healthy weight, such as eating a healthy diet and exercising regularly.
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Trusted references:
- National Osteoporosis Foundation: https://www.bonehealthandosteoporosis.org/
- Mayo Clinic: https://www.mayoclinic.org/drugs-supplements/raloxifene-oral-route/description/drg-20065760
- UpToDate: https://www.uptodate.com/contents/selective-estrogen-receptor-modulators-and-aromatase-inhibitors-for-breast-cancer-prevention
Tips for maintaining a healthy weight while taking raloxifene:
- Eat a healthy diet that is low in saturated and unhealthy fats, cholesterol, and sodium.
- Eat plenty of fruits, vegetables, and whole grains.
- Exercise regularly. Aim for at least 30 minutes of moderate-intensity exercise most days of the week.
- Talk to your doctor about other ways to manage your weight, such as joining a weight loss support group or seeing a registered dietitian.
- It is more likely to occur in women who are overweight or obese.
- This is more likely to occur in women who take the medication for longer periods of time.
- It is typically modest, with most women gaining less than 5% of their body weight.
- This tablet can usually be controlled with diet and exercise.
- In rare cases, weight gain on raloxifene may be severe and may require discontinuation of the medication.
- Raloxifene may cause weight gain by affecting metabolism and appetite. Raloxifene may slow down the metabolism, which can lead to weight gain. It may also increase appetite, which can also lead to weight gain.
- Raloxifene may also cause fluid retention, which can contribute to weight gain. Fluid retention is a common side effect of raloxifene, and it can occur in up to 20% of women who take the medication.
- Weight gain on raloxifene is typically modest, with most women gaining less than 5% of their body weight. However, in some cases, weight gain can be more severe.
- Weight gain on raloxifene is usually manageable with diet and exercise. However, in some cases, weight loss medications may be necessary.
If you are concerned about weight gain on raloxifene, talk to your doctor. They can help you to develop a plan to maintain a healthy weight and monitor your weight closely.
Here are some additional tips for coping with weight gain on raloxifene:
- Make small changes to your diet and exercise routine. Small changes can add up over time and make a big difference. For example, you could try to eat one less snack per day or walk for an extra 10 minutes each day.
- Find a support system. Having a support system of friends or family members who are also trying to lose weight can help you to stay motivated and on track.
- Don’t give up. Losing weight takes time and effort. Don’t get discouraged if you don’t see results immediately. Just keep working at it, and you will eventually reach your goals.
What are the mechanisms by which raloxifene may cause weight gain?
The exact mechanisms by which raloxifene may cause weight gain are not fully understood, but there are a few possible explanations.
One possible mechanism is that raloxifene may affect metabolism. It is a selective estrogen receptor modulator (SERM), which means that it binds to estrogen receptors in the body and mimics the effects of estrogen in some tissues but not others. In the bones, raloxifene acts like estrogen to stimulate bone growth and prevent osteoporosis. However, in other tissues, such as fat tissue, It may act like an anti-estrogen.
Estrogen plays a role in regulating metabolism, and anti-estrogens can slow down metabolism. This means that the body burns fewer calories at rest, which can lead to weight gain.
Another possible mechanism by which raloxifene may cause weight gain is by affecting appetite. Some studies have shown that raloxifene may increase appetite, which can lead to weight gain.
Finally, It may also cause fluid retention, which can contribute to weight improve. Fluid retention is a common side effect of raloxifene, and it can occur in up to 20% of women who take the medication.
Who is at increased risk of it?
Certain women are at increased risk of weight gain on raloxifene, including:
- Women who are overweight or obese
- Women who take raloxifene for longer periods of time
- Women who have a history of weight improve
- Women with certain medical conditions, such as diabetes or hypothyroidism
How much weight gain can be expected from raloxifene?
It is typically modest, with most women gaining less than 5% of their body weight. However, in some cases, It can be more severe.
One study found that women who took raloxifene for 5 years gained an average of 2.6 pounds. However, some women in the study gained more than 10 pounds.
How can weight gain be managed?
This can usually be managed with diet and exercise.
Here are some tips for managing it:
- Eat a healthy diet that is low in saturated and unhealthy fats, cholesterol, and sodium.
- Eat plenty of fruits, vegetables, and whole grains.
- Exercise regularly. Aim for at least 30 minutes of moderate-intensity exercise most days of the week.
- Talk to your doctor about other ways to manage your weight, such as joining a weight loss support group or seeing a registered dietitian.
In rare cases,It may be severe and may require discontinuation of the medication.
What are the risks and benefits of raloxifene?
It is a safe and effective medication for many women. It has been shown to reduce the risk of osteoporosis and invasive breast cancer in high-risk women. However, like all medications, raloxifene has some potential side effects, including weight i.
If you are concerned about weight gain on raloxifene, talk to your doctor. They can help you to develop a plan to maintain a healthy weight and monitor your weight closely.
Here are some additional tips for coping with weight gain on raloxifene:
- Don’t get discouraged. It is a common side effect of raloxifene, and it is usually manageable with diet and exercise.
- Talk to your doctor. Your doctor can help you to develop a weight loss plan that is safe and effective for you.
- Eat a healthy diet. Eating a healthy diet can help you to lose weight and improve your overall health.
- Exercise regularly. Exercise is another important part of weight loss. Aim for at least 30 minutes of moderate-intensity exercise most days of the week.
- Be patient. Losing weight takes time and effort. Don’t expect to see results overnight.
If you experience any weight gain while taking raloxifene, talk to your doctor. They can help you to determine if the weight gain is related to the medication and recommend appropriate treatment options. talk to your doctor if you are facing any major issue.
